Kamoo Banna le Basali ba Sebetsang Tsamaiso ea Tšabo Mehopolo

Ka Boko ba Bokooa le Boitšoaro

Banna le basali ba na le ts'oaetso e fapaneng ea khatello ea maikutlo le mathata a amanang le khatello ea maikutlo joalo ka ho tšoenyeha le khatello ea maikutlo ea khatello ea maikutlo (PTSD), lithuto tsa khale li senotse. Ka mohlala, basali ba tšoaroa ke PTSD ka makhetlo a mabeli ho feta a banna. Bafuputsi ba batla ho tseba hore na hobaneng ho le joalo.

Bopaki bo ntseng bo hola bo supa hore banna le basali ba tšosa mehopolo ka tsela e fapaneng. Patlisiso e ncha litoeba tse tsoang sehlopheng se etelletsoeng pele ke Mofuputsi e Mocha oa BBRF Elizabeth A. Heller, Ph.D., oa Univesithi ea Pennsylvania, e theha mekhoa e meng e amehang. Ho utloisisa mekhoa ena ho ka thusa kholisong ea nako e tlang ea kalafo e ikhethileng ea thobalano bakeng sa mathata a ho tšoenyeha.

Liphetho tsa morao-rao tsa sehlopha li tlalehiloe inthaneteng ho Biological Psychiatry ka la 5 Tšitoe 2018. Ba fana ka maikutlo a hore taolo ea lefutso e bitsoang Cdk5 ke mohloli oa bohlokoa oa phapang tseleng eo banna le basali ba sebetsanang le tšabo ea ho hopola lintho. Liphapang li ile tsa bonoa ho hippocampus ea boko, setsi sa mohopolo, ho ithuta, le boemo ba sebaka.

Khopolo ea ho iphetola ha lintho e hlahisitse mekhoa e fapaneng eo lisele li laolang tšebetso ea liphatsa tsa lefutso ka tsela eo li li bulelang le ho tima ka eona ka linako tse itseng. Mokhoa oa taolo o amanang le Cdk5 le ts'ebetso ea likhopotso tsa tšabo o bitsoa taolo ea epigenetic. Mofuta ona oa taolo ea liphatsa tsa lefutso ke litholoana tsa liphetoho tsa limolek'hule, tse bitsoang matšoao a epigenetic, tse eketsoang kapa tse tlosoang tatelanong ea DNA e "hlabang" liphatsa tsa lefutso. Ka ho eketsa kapa ho tlosa matšoao a epigenetic, lisele li khona ho kenya tšebetsong kapa ho koala liphatsa tse itseng tsa lefutso.

Ho sebelisa litoeba e le tse emelang batho-boko ba mouse bo tšoana haholo lintlheng tse ngata, ho kenyeletsoa le mekhoa ea taolo ea liphatsa tsa lefutso-Dr. Heller le basebetsi-'moho le eena ba fumane hore ho fumana likhopotso tsa tšabo ka nako e telele ho matla ho banna ho feta basali. Lebaka: keketseho ea ts'ebetso ea Cdk5 ho banna, e bakoang ke matšoao a epigenetic. Ts'ebetso e hlaha liseleng tsa methapo ho hippocampus.

Ba sebelisa mokhoa o mocha oa ho hlophisa epigenetic, Dr. Heller le basebetsi-'moho ba ile ba khona ho fumana karolo e ikhethileng ea basali ea ts'ebetso ea Cdk5 ho fokotseng ho khutlisoa ha mehopolo ea tšabo. Sena se bile le litlamorao tse ikhethileng tsa basali lethathamong la likokoana-hloko la liketso kamora ho ts'oaroa ha liphatsa tsa lefutso.

Lintho tsena tse sibollotsoeng ke karolo ea kutloisiso ea rona e ntseng e hola ea phapang ea thobalano ho baeloji ea kamoo liketsahalo tse tšosang li hopoloang le ho fana ka maikutlo a hore hobaneng thobalano e le karolo ea bohlokoa bothateng ba boko le boits'oaro bo amang tšabo le khatello ea maikutlo, joalo ka PTSD, khatello ea maikutlo le matšoenyeho.