Ho holisa tšitiso ea tšebetso ea mali

Ka Boko ba Bokooa le Boitšoaro

Bafuputsi ba etelletsoe pele ke mofuputsi e monyane oa 2016 BBRF Ethan Lippmann, Ph.D., ba tlaleha hore ba atlehile ho "aha" masapo a methapo a sebetsang joalo ka lera la bohlokoa la ts'ireletso la boko, le bitsoang mokoallo oa mali le bokong. Tšitiso e sebetsa joaloka sefe e khethang, e bolokang limolek'hule tse kholo ho kenyelletsa le libaktheria tse tsoang bokong le mokelikeli oa mokokotlo, empa e lumella oksijene, tsoekere le lintho tse ling tsa bohlokoa ho kena.

Mosebetsi o etsoang Univesithing ea Vanderbilt mme o phatlalalitsoe ka la 14 Hlakola 2019 ho Stem Cell Reports, o lokela ho thusa ho potlakisa phetolelo ea mehopolo ea mahlale ho etsa lipatlisiso bokong.

Le ha litso tsa lisele tse peli tsa boko li 'nile tsa lengoa nakong e fetileng, lena ke lekhetlo la pele mofuta oa likarolo tse tharo o sebetsang joalo ka mokoallo oa mali le boko ba motho o entsoe. Moetso o holisoa ho tloha liseleng tse tsoang sampole ea motho e hlohlellelitsoeng ho itlhahisa e le mofuta o khethehileng oa sele e leng motheo oa tšitiso ea mali le bokong. Ebe li bokelloa ka matrix a mahlakore a mararo a sebetsang joalo ka sekwere.

Mokhoa oa ho etsa li-cell-reprogramming o qalileng lipatlisisong tsa boko ke bafani ba BBRF le ba bang lilemong tse leshome tse fetileng, o bitsoa iPSC, e emelang theknoloji ea "cell pluripotent stem cell". E na le lits'ebetso tse ngata ho pholletsa le bongaka, haholoholo ho thehoeng ha mefuta e fapaneng ea "organoids" - e ntseng e phela, litso tse mahlakore a mararo tsa lisele tse hokahantsoeng ho itlhahisa joalo ka mefuta ea lisele e ikhethileng ho litho tse fapaneng tsa 'mele. Tsela e 'ngoe e ts'episang ea ho etsa liteko tsa lithethefatsi le lipatlisiso tsa mafu e thehiloe ho theheng mefuta ea litho tsa motho, ho fumana hore na meriana e sebetsa hantle hakae.

Le ha bafuputsi ba lekile li-organoids tsa mantlha tsa boko, mokhoa o mocha oa ho nchafatsa meaho e phethang karolo ea tšitiso ea mali le bokong ba motho, haeba e kentsoe ho li-organoids tsa bokong, e ka tlisa mahlale a maholo molemong oa ho theha "boko sejaneng" se tšepahalang etsisa sebopeho le tšebetso ea boko ba batho, kapa likarolo tsa tsona.

Ho pheta-pheta tšitiso ea endothelial bokong ba li-organoids ho bohlokoa, hobane boko bo tlameha ho sireletsoa linthong tse maling.

Tšitiso ea mali le bokong e hlaha "ho dutla" mafung a itseng, ho kenyeletsoa le mafu a mang a methapo ho kenyelletsa ALS le lefu la sethoathoa. E boetse e kenella haholoanyane ha ho ruruha 'meleng ho fihla maemong a holimo. Ena e kanna ea ba tsela e le 'ngoe eo limolek'hule tsa ho ruruha li kenang bokong le ts'ebetsong ts'ebetso e tloaelehileng, ka mohlala ho multiple sclerosis.